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Anabolic steroids are performance-enhancing drugs and act by increasing lean muscle protein synthesis and body weight, without increasing fat mass. For this reason, they are regarded as performance indicators. There have been multiple reports of an association between doping and weight management problems, among which anabolic-androgenic steroids are generally considered at the top of the stack.[7,8] Thus, as discussed by the author in a recent letter, if a high proportion of anabolic-androgens is related to weight management problems, an examination of a specific population would be helpful. Furthermore, several studies have indicated that anabolic-androgenic steroids have both positive effects and a negative effect on cardiovascular health (CVD).[7,8] Among this group of drugs, it is an important question that has not yet been tackled. Here, we present a brief review of the use, the mechanisms, and the results of several studies on the effects of anabolic-androgenic steroids on cardiovascular risk. The role of catecholamines in the risk of CVD Adrenergic and noradrenergic mechanisms are involved in the risk of CVD and the risk-reduction of cardiovascular, metabolic, and neurological disorders.[9,10] One study suggests that the intake of anabolic steroids could be associated with lower levels of noradrenaline, a neurotransmitter related to stress and depression, in athletes. Furthermore, the amount of both noradrenaline and dopamine are increased by anabolic-androgenic steroids, suggesting that this increase is mainly related to an increase in plasma steroid concentrations. Several studies, however, have shown no association between noradrenaline levels and plasma levels or the effects of anabolic-androgenic steroids. Moreover, in a recent study published for the European Society of Human Nutrition and Health, the anabolic steroid levels were comparable to baseline for several healthy subjects at the time of the survey. This is likely to be due to a high level of plasma noradrenaline, which is generally measured with electrocardiography. Also, in a study published for the American Heart Association, the levels of noradrenaline in subjects were not associated with the concentration and duration of anabolic-androgenic steroid treatment. Also, a study of the same population as the aforementioned study reported that athletes and recreationally active men had the highest noradrenaline (norepinephrine) levels of the study population. Therefore, despite the relatively low prevalence of noradrenaline levels, anabolic-androgenic steroid therapy is associated with an increase the nor Related Article: